Metalyse Full Prescribing Information | 藥師百科
METALYSEisindicatedforthethrombolytictreatmentofacutemyocardialinfarction(AMI).Treatmentshouldbeinitiatedassoonaspossibleaftersymptomonset ...
Pharmacology: Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA. After administration of tenecteplase dose dependent consumption of α2-antiplasmin (the fluid-phase inhibitor of plasmin) with consequent increase in the level of systemic plasmin generation have been observed. This observation is consistent with the intended effect of plasminogen activation. In comparative studies a less than 15% reduction in fibrinogen and a less than 25% reduction in plasminogen were observed in subjects treated with the maximum dose of tenecteplase (1...
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Metalyse (tenecteplase) Drug Medicine Information | 藥師百科
Metalyse is used during the early stages of a heart attack. This medicine belongs to a group of medicines called tissue plasminogen activators (t-PA). It works ... Read More
Metalyse - European Medicines Agency | 藥師百科
Metalyse | 藥師百科
Metalyse is used during the early stages of a heart attack. This medicine belongs to a group of medicines called tissue plasminogen activators (t-PA). It works ... Read More
Metalyse 10 | 藥師百科
Metalyse is indicated in adults for the thrombolytic treatment of suspected myocardial infarction with persistent ST elevation or recent left Bundle Branch ... Read More
Metalyse Full Prescribing Information | 藥師百科
METALYSE is indicated for the thrombolytic treatment of acute myocardial infarction (AMI). Treatment should be initiated as soon as possible after symptom onset ... Read More
Metalyse, INN-Tenecteplase | 藥師百科
Metalyse is indicated in adults for the thrombolytic treatment of suspected myocardial infarction with persistent ST elevation or recent left Bundle Branch ... Read More
Metalyse: Uses, Side Effects | 藥師百科
Metalyse is used to treat adults suspected of having an acute myocardial infarction (heart attack) within six hours of the first symptoms appearing. It is used ... Read More
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